Morphological studies on the anterior pituitaries of mature female rats receiving injections of pregnancy urine extracts

✍ Scribed by Wolfe, J. M. ;Ellison, E. T. ;Rosenfeld, Louis

• Publisher: John Wiley and Sons
• Year: 1934
• Tongue: English
• Weight: 895 KB
• Volume: 60
• Category: Article
• ISSN: 0003-276X
• DOI: 10.1002/ar.1090600309

✦ Synopsis

It was reported by Wolfc, Phclps and Cleveland ('33) that injection of human placental extracts, rich in the A. P. L.

factor, brought about marked changes in the anterior pituitaries, as well as in the ovaries of immatnre female rats. The ovaries of the injected animals were markedly increased in size, while the pituitaries showed a moderate increase in weight over the controls. The pituitary weight increase was usually greatest in animals in which the ovarian reaction was greatest. Histologically, the pituitaries of the injected animals were markedly altered from the controls. The most outstanding changes were in the basophiles ; these cells were increased in size, but exhibited marked loss of granular material. Xany of the eosinophiles were swollen and also showed evidence of granular loss. Cell counts made on complete serial sections revealed the fact that the percentage of the eosjnophiles was decreased, while that of the chromophobes was increased. Of equal significance was the fact that if the animals were castrated at the beginning of the