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Morphological evidence for the folding of polyproline II helices

✍ Scribed by J. C. Andries; A. G. Walton

Book ID
102762284
Publisher
Wiley (John Wiley & Sons)
Year
1969
Tongue
English
Weight
547 KB
Volume
8
Category
Article
ISSN
0006-3525

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✦ Synopsis

Spherulites of poly-L-proline I1 were grown by film casting from a dilute formic acid solution. Electron diffraction indicated that the molecular axis was parallel to the surface and essentially normal to the face of the lamellae. The molecular length was five times greater than the width of the lamellae. This is considered to be substantial evidence for the molecular folding of poly-L-proline 11. A correlation between the molecular conformation of poly-L-proline in solution and the observed morphological form in the solid state has been determined. As the solution mutarotates from form I to form 11, the solid morphology varies from an indistinctly shaped spherulite with little inner detail to a well formed crystalline spherulite complete with lamellae.

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