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Morphological and gene expression analysis in mouse primary cultured hepatocytes exposed to streptozotocin

✍ Scribed by Eisuke Kume; Chinami Aruga; Kaori Takahashi; Satoko Miwa; Eriha Dekura; Masahito Itoh; Yukiko Ishizuka; Hisako Fujimura; Wataru Toriumi; Kunio Doi

Book ID
118436073
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
678 KB
Volume
56
Category
Article
ISSN
0940-2993

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## Abstract High concentrations of tumor necrosis factor Ξ± (TNFΞ±) are cytotoxic to cultured hepatocytes. Impairment of energy metabolism and generation of an intracellular oxidant stress are important events in the pathogenesis of this toxicity (6). In the present study, we have examined the role o