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Morphological and biological modifications in human fibroblast primary cultures during cellular aging

✍ Scribed by CARDELLI, P; SCARPA, S; MASUELLI, L; MODESTI, A


Book ID
122273980
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
130 KB
Volume
14
Category
Article
ISSN
0309-1651

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Transcriptional activation of c-fos in response to both serum stimulation and D N A damage requires the serum response element. The inability of in vitro aged or senescent fibroblasts to proliferate in response to serum has been shown to be associated with repressed c-fos expression and reduced AP-1