Morphologic characteristics of acute lymphoblastic leukemia (ALL) with abnormalities of chromosome 8, band q24
β Scribed by Dr. F. R. Davey; D. Lawrence; J. Maccallum; J. Varney; R. Hutchison; D. Wurster-Hill; C. Schiffer; R. E. Sobol; N. Ciminelli; M. le Beau; C. D. Bloomfield
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 720 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0361-8609
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Clonal abnormalities of chromosome(s) 7 were investigated in two patients with acute lymphoblastic leukemia. The abnormal karyotypes were 46,XY.-7,de1(6)(qI 3qZl),+i(7q)/47,XY,deI(6),+i(7q) in case I, and 46,XX.-7,t(4;1 l)(qZl;q23), + i(7q) in case 2. DNA from leukemic tissue was investigated with S
## Abstract ## BACKGROUND Elderly patients with Philadelphia chromosomeβpositive acute lymphoblastic leukemia (Ph+ALL) have a poor prognosis, with a low complete remission (CR) rate, high induction mortality, and short remission duration. Imatinib (IM) has a favorable toxicity profile but limited