๐”– Bobbio Scriptorium
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Morphologic changes in extraocular muscles of the dystrophic hamster

โœ Scribed by Dr. D. H. Percy; Dr. J. H. Thakar; Dr. K. P. Strickland

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
950 KB
Volume
2
Category
Article
ISSN
0148-639X

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โœฆ Synopsis

Abstract

Cardiomyopathic hamsters (UMโ€X7.1 strain) have demonstrable myopathy involving both skeletal and cardiac muscle. In addition, they have multiple ocular abnormalities. In this study, extraocular muscles were examined by light and electron microscopy. Changes observed within affected muscle fibers were variable and included coagulation necrosis, lysis of myofibrils, mitochondrial changes, and infiltration by phagocytic cells. Regenerative changes included duplication of myoblast nuclei, proliferation of sarcoplasmic reticulum, and myofibrillogenesis. The lesions are presumably myogenic in origin. The cardiomyopathic hamster may be useful as an animal model for certain types of ocular myopathy in man.

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## Abstract Extraocular muscles from representative species of vertebrate groups ranging from amphibians to the higher mammals were examined in serial histological sections for the presence of muscle spindles. These observations and data from the literature indicate that extraocular muscles of the