Morphologic and cytogenetic studies in vitro of surface-adherent lymphoreticular cells derived from burkitt lymphoma tissue
✍ Scribed by A. S. Rabson; E. W. Chu; I. K. Berezesky; F. Y. Legallais; P. M. Grimley
- Book ID
- 102863395
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- French
- Weight
- 672 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
A line of lymphoreticular cells (AL‐1‐G) that can adhere to glass surfaces has been derived from suspension cultures of Burkitt lymphoma cells (AL‐1). By light microscopy, the predominant cell type in the AL‐1‐G cultures has features of a neoplastic histiocyte and ultrastructurally these cells have more elaborate development of cytoplasmic organelles, such as elements of the Golgi complex and mitochondria, than the predominant cell types in the suspension cultures of AL‐1. Cytogenetically, the percentage of polyploid cells in the AL‐1‐G cultures increased progressively from 39% in 1967 to 100% in 1968 and 1969, while the percentage of polyploid cells in the suspension cultures remained between 12 and 24% during the same period. No herpesvirus or any other type of viral particle was found in the AL‐1‐G cultures on repeated electron microscopic examination.