✦ LIBER ✦

Morphogens in vertebrate development: How do they work?

✍ Scribed by Jonathan Cooke

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 541 KB
Volume: 17
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950170202

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The idea that concentration gradients of crucial substances might control the pattern of development, even in the embryos of complex organisms, has been around for a long time, but mostly in obscure forms. Twenty five years ago clear, experimentally testable ideas about how such gradients might work were enunciated, and more recently the morphogen gradient principle was shown to underlie the beginnings of patterning in Drosophila. Is it also central to vertebrate development? Four recent papers raise experimentation to a new level^(1–4)^, while showing how difficult it might be to pin down the precise form of the mechanism.

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