Morphogenetic interactions between minced limb muscle and transplanted blastemas in the axolotl
✍ Scribed by Dinsmore, Charles E.
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- English
- Weight
- 757 KB
- Volume
- 187
- Category
- Article
- ISSN
- 0022-104X
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✦ Synopsis
Abstract
The regeneration blastema when autoplastically transplanted to the enucleated orbit of a larval axolotl will differentiate only those structures which lie distal to the level of its origin. Minced limb muscle treated in the same manner will reorganize into muscle, however imperfect, but form no regenerate. When a distal limb blastema is superimposed on minced limb muscle in the orbital site, it produces structures proximal as well as distal to the original level of amputation. Epimorphic regeneration therefore appears to be dominant over tissue regeneration of minced muscle and hypermorphogenesis may be elicited from a distal blastema by augmenting the mesenchymal mass with minced limb muscle.