Morphogenesis of acidophilic bodies in experimental D-Galactosamine induced hepatitis
โ Scribed by Oda, M. ;Funatsu, K. ;Okazaki, I. ;Kamegaya, K. ;Tsuchiya, M. ;Sambe, K.
- Publisher
- Springer-Verlag
- Year
- 1973
- Tongue
- English
- Weight
- 72 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0435-1339
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Galactosamine induces a dose-dependent hepatic injury in rats and many other animals. The toxicity of Dgalactosamine appears to be a consequence of the loss of hepatic UTP. It has previously been reported that regenerating liver cytosol is able to prevent, at least in part, the lethal effect of this
## Abstract This study was designed to investigate the influence of 2โmethylโ6โphenylethynyl pyridine hydrochloride (MPEP), an antagonist of metabotropic glutamate receptor subtype 5, in lipopolysaccharide (LPS) and dโgalactosamine (dโGalN)โinduced fulminant hepatic failure in mice. Mice were given