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Morphine induced saccharin aversion in α-methyltyrosine pretreated rats

✍ Scribed by Wayne R. Coussens; William F. Crowder; W. Marvin Davis

Publisher: Springer
Year: 1973
Tongue: English
Weight: 426 KB
Volume: 29
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00422647

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✦ Synopsis

Rats pretreated with L-a-methyltyrosine (AMT) and then given pairings of saccharin drinking and morphine infusion subsequently showed a reduced preference for saccharin over water, when compared with control rats. Control conditions were A_~T pretreatment with saccharin-saline pairings, saline pretreatment with saccharin-morphine pairings, and saline pretreatment with saccharinsaline pairings. A second experiment also showed significantly greater saccharin aversion with morphine-infused, AMT-pretreated rats than with saline-infused, AMT-pretreated rats although the morphine dosage was lower than that used in Experiment 1. These results suggest that morphine is aversive to rats that have been treated with AMT.

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