✦ LIBER ✦

Morphine dependence in the rat: The appearance in the spinal cord of a dorsal root ganglion cell neurotrophic factor

✍ Scribed by Dr. I. A. Hendry; A. W. Duggan; J. G. Hall

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 373 KB
Volume: 18
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490180309

No coin nor oath required. For personal study only.

✦ Synopsis

An increase in neurotrophic activity for the survival of dissociated sensory neurones has been found in the spinal cord of morphine dependent rats. This activity is not due to morphine itself and is not due to an increase in the nerve growth factor as antibodies to nerve growth factor fail to block the response. A new hypothesis is presented that some of the spinal effects of morphine dependence may be due to an increase in the level of neurotrophic factors as a response to an apparent denervation of the target cells in the spinal cord.

📜 SIMILAR VOLUMES

A-fiber sensory input induces neuronal c

A-fiber sensory input induces neuronal cell death in the dorsal horn of the adult rat spinal cord

✍ Richard E. Coggeshall; Helena A. Lekan; Fletcher A. White; Clifford J. Woolf 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 339 KB

The caliber of central and peripheral ne

The caliber of central and peripheral neurites of spinal ganglion cells and variations in fiber size at different levels of dorsal spinal roots

✍ Bror Rexed; Patrik Sourander 📂 Article 📅 1949 🏛 John Wiley and Sons 🌐 English ⚖ 491 KB 👁 2 views

Intrinsic versus extrinsic factors in de

Intrinsic versus extrinsic factors in determining the regeneration of the central processes of rat dorsal root ganglion neurons: The influence of a peripheral nerve graft

✍ Chong, M.S.; Woolf, C.J.; Turmaine, M.; Emson, P.C.; Anderson, P.N. 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 967 KB

The relative contribution of intrinsic growth capacity versus extrinsic growth-promoting factors in determining the capacity of transected dorsal root axons to regenerate long distances was studied. L4 dorsal root axons regenerating into 4-cm peripheral nerve grafts on transected dorsal roots were c

The homeodomain transcription factor Gbx

The homeodomain transcription factor Gbx1 identifies a subpopulation of late-born GABAergic interneurons in the developing dorsal spinal cord

✍ Anita John; Hendrik Wildner; Stefan Britsch 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 298 KB

Glial cell line-derived neurotrophic fac

Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of axotomized retinal ganglion cells in adult rats: Comparison to and combination with brain-derived neurotrophic factor (BDNF)

✍ Yan, Qiao ;Wang, Jue ;Matheson, Christine R. ;Urich, Janal L. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 842 KB

Adult rat retinal ganglion cells (RGC) undergo degeneration after optic nerve transection. Studies have shown that exogenously applied neurotrophic factors such as brain-derived neurotrophic factor (BDNF) can attenuate axotomy-induced as well as developmental RGC death. Here, we examined whether gli

Quantitative and neurogenic analysis of

Quantitative and neurogenic analysis of neurons with supraspinal projections in the superficial dorsal horn of the rat lumbar spinal cord

✍ Tulsi N. Bice; John A. Beal 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 175 KB 👁 3 views

Dual retrograde axonal tracers, Fluoro-Gold (FG) and true blue (TB), were used in conjunction with [ 3 H]thymidine autoradiography to determine the number and neurogenic pattern of neurons with supraspinal projections in the superficial dorsal horn (SDH), i.e., laminae I and II, in spinal segment L1