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Morphine Antinociception Is Enhanced in mdr1a Gene-Deficient Mice

✍ Scribed by Jian Zong; Gary M. Pollack

Book ID: 110251387
Publisher: Springer US
Year: 2000
Tongue: English
Weight: 192 KB
Volume: 17
Category: Article
ISSN: 0724-8741
DOI: 10.1023/a:1007546719287

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## Abstract A subpopulation of the CF‐1 mouse strain is sensitive to neurotoxicity following exposure to avermectins, a family of structurally related antiparasitic agents. This unusual sensitivity is the result of a deficiency in the mdr1a P‐glycoprotein that normally contributes to a functional b