𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Morita-Baylis-Hillman Approach toward Formal Total Synthesis of Tamiflu and Total Synthesis of Gabaculine

✍ Scribed by Bhowmik, Subhendu; Batra, Sanjay


Book ID
121087110
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
555 KB
Volume
2013
Category
Article
ISSN
1434-193X

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Acyloins from Morita–Baylis–Hillman addu
✍ Giovanni W. Amarante; Patrícia Rezende; Mayra Cavallaro; Fernando Coelho 📂 Article 📅 2008 🏛 Elsevier Science 🌐 French ⚖ 137 KB

In this Letter, we describe an easy and straightforward strategy for the preparation of acyloins (a-hydroxyketones) from Morita-Baylis-Hillman adducts, based on a Curtius rearrangement. Different acyloins were obtained with good overall yield (>40% for three steps). To exemplify the synthetic useful

Highly diastereoselective total synthesi
✍ Giovanni W. Amarante; Mayra Cavallaro; Fernando Coelho 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 285 KB

We disclose herein a new approach for the highly diastereoselective total synthesis of the anti-tumoral agent (±)-Spisulosine. The synthesis was accomplished in seven steps with an overall yield of 10%. The key step involves the transformation of a Morita-Baylis-Hillman into an acyloin, which was su