Morita-Baylis-Hillman Approach toward Formal Total Synthesis of Tamiflu and Total Synthesis of Gabaculine
✍ Scribed by Bhowmik, Subhendu; Batra, Sanjay
- Book ID
- 121087110
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 555 KB
- Volume
- 2013
- Category
- Article
- ISSN
- 1434-193X
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📜 SIMILAR VOLUMES
In this Letter, we describe an easy and straightforward strategy for the preparation of acyloins (a-hydroxyketones) from Morita-Baylis-Hillman adducts, based on a Curtius rearrangement. Different acyloins were obtained with good overall yield (>40% for three steps). To exemplify the synthetic useful
We disclose herein a new approach for the highly diastereoselective total synthesis of the anti-tumoral agent (±)-Spisulosine. The synthesis was accomplished in seven steps with an overall yield of 10%. The key step involves the transformation of a Morita-Baylis-Hillman into an acyloin, which was su