𝔖 Bobbio Scriptorium
✦   LIBER   ✦

More Flexibility on Drugs

Book ID
109670982
Publisher
Nature Publishing Group
Year
1970
Tongue
English
Weight
232 KB
Volume
225
Category
Article
ISSN
0028-0836

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The internal Β―exibility of the central seven-membered ring of a series of tricyclic antidepressant drugs (TCAs), imipramine {1}, amitriptyline{2}, doxepin {3}, and dothiepin {4}, has been investigated by 1 H and 13 C nuclear magnetic (NMR) techniques. Two dynamic processes were examined: ring invers