Moonlighting Cell Stress Proteins in Microbial Infections

✍ Scribed by Peter A. Lund (auth.), Brian Henderson (eds.)

• Publisher: Springer Netherlands
• Year: 2013
• Tongue: English
• Leaves: 409
• Series: Heat Shock Proteins 7
• Edition: 1
• Category: Library

✦ Synopsis

Microbial infection is increasingly seen as a problem as we begin to run out of antibiotics. Understanding how microbes cause disease is essential. In recent years it has begun to emerge that bacteria, fungi, protozoa and viruses can use their cell stress proteins to cause infection. This volume brings together the world's leading experts in the study of the microbial and human cell stress proteins that are involved in enabling microorganisms to infect humans and cause serious disease.

✦ Table of Contents

Front Matter....Pages i-xvii
Front Matter....Pages 1-1
Bacterial Stress Responses....Pages 3-22
A Brief Introduction to the Eukaryotic Cell Stress Proteins....Pages 23-50
New Ideas on Protein Moonlighting....Pages 51-66
Front Matter....Pages 67-67
Chaperonin 10, a Pro- and Anti-inflammatory Host Modulator....Pages 69-80
Helicobacter pylori Peptidyl Prolyl cis, trans Isomerase: A Modulator of the Host Immune Response....Pages 81-91
Macrophage Infectivity Potentiator Mip Exhibits Peptidyl-Prolyl- cis/trans -Isomerase Activity, Binds Collagen IV and Enables Legionella pneumophila to Transmigrate Across Tissue Barriers....Pages 93-99
Evolution of Bacterial Chaperonin 60 Paralogues and Moonlighting Activity....Pages 101-121
Mycobacterium tuberculosis Chaperonin 60 Paralogues Contribute to Virulence in Tuberculosis....Pages 123-141
The Legionella pneumophila Chaperonin 60 and the Art of Keeping Several Moonlighting Jobs....Pages 143-160
Chaperonin 60.1 of the Chlamydiae (cHSP60) as a Major Virulence Determinant....Pages 161-172
Insect Symbiotic Bacterial GroEL (Chaperonin 60) and Plant Virus Transmission....Pages 173-187
Histoplasma capsulatum Chaperonin 60: A Novel Adhesin and Vaccine Candidate....Pages 189-202
The Role of Stress-Induced Activation of HSP70 in Dendritic Cells, CD4 + T Cell, Memory and Adjuvanticity....Pages 203-221
Candida albicans Ssa: An Hsp70 Homologue and Virulence Factor....Pages 223-235
Hsp90 Plays a Role in Host-Bacterial Interactions: Insight Gained from Acanthamoeba castellanii ....Pages 237-248
Front Matter....Pages 249-249
Role of Peptidyl-Prolyl cis/trans Isomerases in Cellular Uptake of Bacterial Protein Toxins....Pages 251-265
Listeria monocytogenes and Host Hsp60 – An Invasive Pairing....Pages 267-282
Cell Surface Stress Proteins and the Receptor for Lipopolysaccharide....Pages 283-292
Host Molecular Chaperones: Cell Surface Receptors for Viruses....Pages 293-307
BiP (Grp78): A Target for Escherichia coli Subtilase Cytotoxin....Pages 309-322
Front Matter....Pages 249-249
Cholera Toxin Interactions with Host Cell Stress Proteins....Pages 323-338
Endoplasmic Reticulum Stress-Associated gp96 Chaperone is a Host Receptor for Adherent-Invasive E . coli ....Pages 339-352
Escherichia coli K1 Meningitis and Heat Shock Protein, gp96....Pages 353-371
Front Matter....Pages 373-373
Bacterial Cell Stress Protein ClpP: A Novel Antibiotic Target....Pages 375-385
Host Neuroendocrine Stress Hormones Driving Bacterial Behaviour and Virulence....Pages 387-398
Back Matter....Pages 399-406

✦ Subjects

Biomedicine general;Protein Science;Microbiology;Bacteriology