Mood states, sympathetic activity, and in vivo β-adrenergic receptor function in a normal population
✍ Scribed by Bum-Hee Yu; Eun-Ho Kang; Michael G. Ziegler; Paul J. Mills; Joel E. Dimsdale
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 94 KB
- Volume
- 25
- Category
- Article
- ISSN
- 1091-4269
- DOI
- 10.1002/da.20338
No coin nor oath required. For personal study only.
✦ Synopsis
The purpose of this study was to examine the relationship between mood states and b-adrenergic receptor function in a normal population. We also examined if sympathetic nervous system activity is related to mood states or b-adrenergic receptor function. Sixty-two participants aged 25-50 years were enrolled in this study. Mood states were assessed using the Profile of Mood States (POMS). b-adrenergic receptor function was determined using the chronotropic 25 dose isoproterenol infusion test. Level of sympathetic nervous system activity was estimated from 24-hr urine norepinephrine excretion. Higher tension-anxiety, depression-dejection, and anger-hostility were related to decreased b-adrenergic receptor sensitivity (i.e., higher chronotropic 25 dose values), but tension-anxiety was the only remaining independent predictor of b-adrenergic receptor function after controlling for age, gender, ethnicity, and body mass index (BMI). Urinary norepinephrine excretion was unrelated to either mood states or b-adrenergic receptor function. These findings replicate previous reports that anxiety is related to decreased (i.e., desensitized) b-adrenergic receptor sensitivity, even after controlling for age, gender, ethnicity, and body mass index.