Mood disorder following DBS of the left amygdaloid region in a dystonia patient with a dislodged electrode
✍ Scribed by Sylvie Piacentini; Luigi Romito; Angelo Franzini; Alberto Granato; Giovanni Broggi; Alberto Albanese
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 101 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0885-3185
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✦ Synopsis
Abstract
Continuous high‐frequency stimulation of the globus pallidum internum (GPi) is an accepted treatment for patients with primary dystonia. In a series of 18 consecutive dystonia cases that were successfully treated by bilateral GPi stimulation, 1 patient had an adverse event involving the downward migration of the electrodes. He developed remarkable behavioral complications and was found to have dislodgement of the left electrode to a position close to the left amygdala. The patient developed behavioral changes consisting of depression, psychotic symptoms, and heightened pain perception. This syndrome reverted when the left electrode was removed and a new one inserted in the correct position. We describe in detail the clinical features associated with left amygdala dysregulation induced by high‐frequency stimulation through the displaced electrode. © 2007 Movement Disorder Society