## Abstract Genetic data from founder populations are advantageous for studies of complex traits that are often plagued by the problem of genetic heterogeneity. However, the desire to analyze large and complex pedigrees that often arise from such populations, coupled with the need to handle many li
Monte Carlo analysis on a large pedigree
β Scribed by Dr. E. A. Thompson; S. Lin; A. B. Olshen; E. M. Wijsman
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 404 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
β¦ Synopsis
Monte Carlo methods for linkage and segregation analysis are applied to the HGARl pedigree. To address these data, the methods are extended in several ways. The results are compared with those provided by PAP.
π SIMILAR VOLUMES
The MORGAN package of programs is compared to a commonly used package, PAP, with respect to model selection in segregation analysis of a quantitative trait. MORGAN uses Monte Carlo Markov chain (MCMC) methods to estimate the likelihood, whereas both versions of PAP used employ an approximation to th
## Abstract Tourette syndrome (TS) is a neuropsychiatric disorder characterized by multiple motor and phonic tics. The heritability of TS has been well established, yet there is a lack of consensus in genomeβwide linkage studies. The purpose of this study was to conduct a genomeβwide linkage analys