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Monozygotic twins discordant for trisomy 21

✍ Scribed by Rogers, John G. ;Voullaire, Lucille ;Gold, Hugo ;Opitz, John M.

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 202 KB
Volume: 11
Category: Article
ISSN: 0148-7299
DOI: 10.1002/ajmg.1320110204

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✦ Synopsis

Abstract

Monochorionic twins were phenotypically discordant for Down syndrome. Chromosome analysis of lymphocytes showed both to be mosaics. Fibroblast chromosome analysis showed that one twin was 46,XY and the other 47,XY, +21. Blood mosaicism appears to have resulted from placental anastomoses. The twins are presumed to be monozygotic on the basis of placentation, identical blood groups, HLA haplotypes, and serum proteins. We offer some speculation on the manner of occurrence of this rare event.

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