Improved survival in childhood acute lymphoblastic leukemia has led to the occurrence of second malignancies in these patients. Hodgkin's disease is very rare as a second malignancy. We report three patients with acute lymphoblastic leukemia in remission who developed Hodgkin's disease. Al- though a
Monosomy 20: A nonrandom finding in childhood acute lymphoblastic leukemia
β Scribed by Dr. David R. Betts; Judith E. Kingston; Elaine L. Dorey; Bryan D. Young; David Webb; Fay E. Katz; Barbara Gibbons
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 277 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1045-2257
No coin nor oath required. For personal study only.
β¦ Synopsis
We describe four cases of childhood acute lymphoblastic leukemia with monosomy 20 as the sole cytogenetic abnormality. These cases represent 3.4% of cytogenetically abnormal childhood ALL studied in our institute at diagnosis. The patients presented at similar age, ranging from 3 I t o 36 months. All four patients remain in first remission with survival time being at least 20 months from the time of diagnosis.
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To determine the incidence of thrombocytosis at presentation in acute lymphoblastic leukemia (ALL), medical records of all children diagnosed at the Children's Hospital of Pittsburgh from 1980 to 1987 were reviewed. Out of 217 such patients, 7 (3.2%) had platelet counts greater than 400,000/mm3. All
## Background. In childhood acute lymphoblastic leukemia (ALL), the relationship between lymphoblast L1/L2 morphology and prognosis is controversial. According to some studies L2 morphology is associated with poor prognosis, whereas in others the association disappears after adjustment for other k