Mononuclear subsets during cytomegalovirus disease in renal transplant recipients treated with cyclosporine and rabbit antithymocyte globulin

✍ Scribed by H. J. Metselaar; Ph. H. Rothbarth; G. J. Wenting; L. B. Vaessen; N. Masurel; J. Jeekel; W. Weimar

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 363 KB
• Volume: 19
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/jmv.1890190114

✦ Synopsis

The effect of cytomegalovirus (CMV) disease on mononuclear subpopulations of 49 renal transplant recipients treated with cyclosporine and prednisone are reported. Clinical overt CMV infection developed in 8/21 patients treated for rejection with rabbit antithymocyte globulin. They all showed true inversions of the T helper/T suppressor-cytotoxic (Th/Ts-c) ratio. A reduction of T helper cells and increase in T suppressor-cytotoxic cells preceded clinical symptoms of CMV disease by one week. None of the 26 patients without RATG anti-rejection treatment developed CMV disease and in only three of them an inversion of Th/Ts-c ratio was found.