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Monoglucosylated glycans in the secreted human complement component C3: implications for protein biosynthesis and structure

✍ Scribed by M.D. Max Crispin; Gayle E. Ritchie; Alison J. Critchley; B. Paul Morgan; Ian A. Wilson; Raymond A. Dwek; Robert B. Sim; Pauline M. Rudd


Book ID
116464455
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
224 KB
Volume
566
Category
Article
ISSN
0014-5793

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Human CD59 is a small membrane-bound glycoprotein that functions as an inhibitor of the membrane-attack complex (MAC) of the complement system by binding the complement proteins C8 and C9. The crystal structure of a soluble construct of CD59 has been determined to 2.1 A resolution. When compared wit