Monodisperse Mesoporous Silica Spheres Inside a Bioactive Macroporous Glass–Ceramic Scaffold
✍ Scribed by Renato Mortera; Francesco Baino; Gianluca Croce; Sonia Fiorilli; Chiara Vitale-Brovarone; Enrica Verné; Barbara Onida
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 337 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1438-1656
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✦ Synopsis
Abstract
In the field of bone tissue engineering, monosized MCM‐41 spheres have been incorporated inside a bioactive glass–ceramic macroporous scaffold belonging to the SiO~2~CaOK~2~O (SCK) system so obtaining a multiscale hierarchical composite. The MCM‐41‐SCK system was prepared by dipping the glass–ceramic scaffold into the MCM‐41 synthesis solution and was characterized by means of XRD, micro‐XRD, N~2~ sorption and scanning electron microscopy. The MCM‐41 spheres inside the scaffold are highly uniform in diameter, as those synthesized in powder form. The adsorption capacity of the composite toward ibuprofen is three times higher than that of the MCM‐41‐free scaffold, because of the presence of the ordered mesoporous silica. Also the release behavior in SBF at 37 °C is strongly affected by the presence of MCM‐41 inside the scaffold macropores.