Monocytes and impaired leukocyte migration inhibitory factor production in head and neck squamous carcinoma

✍ Scribed by Beauchamp, Mark L. ;Wolf, Gregory T.

• Book ID: 102849143
• Publisher: Wiley (John Wiley & Sons)
• Year: 1988
• Weight: 669 KB
• Volume: 10
• Category: Article
• ISSN: 0148-6403
• DOI: 10.1002/hed.2890100307

✦ Synopsis

Impaired cell-mediated immunity has been consistently associated with head and neck squamous carcinoma (HNSC). Previous work has implicated monocytes in this impairment. The present study shows that in a subgroup of untreated patients with advanced HNSC, monocytes are responsible for impaired in vitro lymphokine (leukocyte migration inhibitory factor) production. In view of recent studies suggesting interactions between lymphokines and monocytes in the immune response, the present findings may be relevant to future immunotherapeutic approaches. HEAD & NECK SURGERY 10: [187][188][189][190][191][192][193][194]1988 Patients with advanced head and neck squamous carcinoma (HNSC) have consistently displayed evidence of impaired cell-mediated immunity. These impairments have included abnormalities of monocytes and their tissue analogues, macrophages. Recent studies of macrophages from HNSC patients have shown decreased cytotoxicity toward tumor cells' and decreased phagocytic ~a p a b i l i t y . ~? ~ Furthermore, suppression of cellmediated responses by monocytes from HNSC patients has been demonstrated in studies of mixed Supported by Veterans Administration Research Funds.