𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Monocyte α-naphtyl esterase deficiency in chronic granulomatous disease

✍ Scribed by Marie-Anne Gougerot-Pocidalo; Diego Buriot; Claude Griscelli; Jacques Hakim

Book ID
101436637
Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
286 KB
Volume
10
Category
Article
ISSN
0361-8609

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Monocytes from five unrelated children (four boys and a girl) with chronic granulomatous disease were studied for their ability to reduce nitroblue tetrazolium dye after stimulation with zymosan, and for their α‐naphtyl butyrate esterase activity. As expected, monocytes ingested zymosan particles but failed to reduce nitroblue tetrazolium dye. However, monocytes from two boys out of the five patients were α‐naphtyl butyrate esterase‐negative, whereas both their neutrophils and monocytes were positive for granular naphtol AS‐D esterase activity.

📜 SIMILAR VOLUMES

Identification and functional characteri
Identification and functional characterization of two novel mutations in the α-helical loop (residues 484–503) of CYBB/gp91phox resulting in the rare X91+ variant of chronic granulomatous disease
✍ Bernadette Boog; Alex Quach; Maurizio Costabile; Joanne Smart; Patrick Quinn; Ha 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 270 KB

Chronic granulomatous disease (CGD) is mainly caused by mutations in X-linked CYBB that encodes gp91. We have identified two novel mutations in CYBB resulting in the rare X91 + -CGD variant, c.1500T>G (p.Asp500Glu) in two male siblings and c.1463C>A (p.Ala488Asp) in an unrelated male. Zymosan and/or