Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily
✍ Scribed by William S. Modi; Michael Dean; Hector N. Seuanez; Naofumi Mukaida; Kouji Matsushima; Stephen J. O'Brien
- Book ID
- 104665423
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 361 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0340-6717
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✦ Synopsis
Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8, suggested gene symbol IL8) is a cytokine that chemoattracts and activates neutrophils. Using a panel of human-rodent cell hybrids that preferentially segregate human chromosomes and in situ hybridization, the MDNCF/IL-8 gene was placed on the human gene map at position 4q12-q21. This is the same location where at least three other members (platelet factor 4, melanoma growth stimulatory activity, and interferon-gamma induced factor) of the platelet factor 4 gene super-family reside. In addition, a restriction fragment length polymorphism was identified using MDNCF as a probe in screening genomic DNA digested with HindIII from unrelated individuals.