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Monocyclic β-lactam antibiotics produced by bacteria

✍ Scribed by Sykes, R. B.; Cimarusti, C. M.; Bonner, D. P.; Bush, K.; Floyd, D. M.; Georgopapadakou, N. H.; Koster, W. H.; Liu, W. C.; Parker, W. L.; Principe, P. A.


Book ID
109723166
Publisher
Nature Publishing Group
Year
1981
Tongue
English
Weight
344 KB
Volume
291
Category
Article
ISSN
0028-0836

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Monocyclic β-lactam antibiotics
✍ Christopher M. Cimarusti; Richard B. Sykes 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 958 KB

reevaluation of beta-lactam bond deformation as a criterion for a penicillin-like mode-of-action. ## 11. MECHANISM OF ACTION The mechanism of action of the naturally-occurring monobactams was examined at an early They were shown to interact with certain of the penicillin-binding proteins (PBP's) o