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Monoclonal integration of HTLV-I proviral DNA in patients with strongyloidiasis

✍ Scribed by K. Nakada; K. Yamaguchi; S. Furugen; T. Nakasone; K. Nakasone; Y. Oshiro; M. Kohakura; Y. Hinuma; M. Seiki; M. Yoshida; E. Matutes; D. Catovsky; T. Ishii; K. Takatsuki

Publisher
John Wiley and Sons
Year
1987
Tongue
French
Weight
438 KB
Volume
40
Category
Article
ISSN
0020-7136

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✦ Synopsis

The relationship between strongyloidiasis and HTLV-I W ~S Cell suqace marker analysis investigated in Okinawa, an area where both conditions are endemic. Thirty-six patients with strongyloidiasis were serocomplications. Fourteen of these patients (39%) were shown FITC-conjugated monoclonal antibodies OKT4(CD4) and to have monoclonal integration of HTLV-1 proviral DNA in OKT8(CD8) (Ortho, Raritan, NJ). The analysis of the ratio of their blood lymphocytes, a condition designated as "smoul-OKT4+ cells to OKT8+ cells was carried out by laser flow dering" adult T-cell leukaemia (ATL). Monoclonal integration cytometry (Ortho spectrum 111). The normal OKT4/0KT8 of proviral DNA coi;related with an increased CDYCDB ratio ratio was 1.59+0.07 ( m e a n s k ~~) in 66 healthy individuals. and the presence of abnormal lymphocytes in the peripheral blood, and with a trend for greater severity of the parasitic Screening for anti-HEV-I antibodies infection. Although the immunodeficiency caused by HTLV-1 also possible that both the parasitic and the retroviral infestations are important co-factors leading to the development of ATL.

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