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Monoclonal antibody therapy directed against human acute myeloid leukemia stem cells

✍ Scribed by Majeti, R

Book ID
109972640
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
599 KB
Volume
30
Category
Article
ISSN
0950-9232

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Hybridomas producing syngeneic monoclonal antibodies (MAbs) were prepared by fusion of spleen cells of BALB/c mice, which were immunized with sublethal doses of RMB-I cells. This cell line originates from a Rauscher virus (R-MuLV)-induced myeloid leukemia and forms tumors when re-inoculated into mic