Monoclonal antibody targeting of anti-cancer agents
โ Scribed by Baldwin, R.W. ;Byers, V.S.
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 841 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0344-4325
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Monoclonal antibodies (MAbs) to ras, sis, erb-B, src, myb and myc oncoproteins were evaluated for their potential to target anti-cancer drugs to malignant cells. Each antibody was tested for reactivity against both fixed and viable cultured human tumour cells by immunofluorexence, and all reacted ag
## Abstract The monoclonal antibodies LICR-LON M8 and 77-1, which react with epithelial membrane antigen, showed a strong reaction with colorectal cancer on immunohistochemistry. In a radioimmunolocalization study in patients with colorectal cancer, 111In-labelled M8 detected 13 of 16 tumour sites