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Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404

โœ Scribed by L. Otvos Jr.; L. Feiner; E. Lang; G. I. Szendrei; M. Goedert; V. M-Y. Lee

Book ID
102910722
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
556 KB
Volume
39
Category
Article
ISSN
0360-4012

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Paired helical filaments (PHFs) purified from Alzheimer's brain consist of hyperphosphorylated microtubule-associated protein tau. In PHF, phosphorylation occurs at ser/thr tau residues. Several of these ser/thr phosphorylation sites lie immediately C-terminal to the tau tubulin binding domain. The