✦ LIBER ✦

Monoclonal antibody drug conjugates in the treatment of cancer

✍ Scribed by Pamela A Trail; Albert B Bianchi

Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 79 KB
Volume: 11
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(99)00012-6

No coin nor oath required. For personal study only.

✦ Synopsis

Monoclonal antibodies directed to tumor-associated antigens have been chemically conjugated to drugs with different mechanisms of action and different levels of potency. Monoclonal-antibody-directed drug delivery has the potential to both improve efficacy and reduce systemic toxicity. Several immunoconjugates have demonstrated impressive antigenspecific antitumor activity in preclinical models. Phase I trials of a calicheamicin immunoconjugate for treatment of acute myeloid leukemia and a doxorubicin immunoconjugate for treatment of carcinoma have recently been completed.

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