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Monoclonal antibody-coated magnetite particles as contrast agents in magnetic resonance imaging of tumors

✍ Scribed by Sebastian Cerdan; Hans Ruedi Lötscher; Basil Künnecke; Joachim Seelig

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
726 KB
Volume
12
Category
Article
ISSN
0740-3194

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✦ Synopsis

A highly specific and powerful magnetic resonance imaging contrast agent has been prepared by coating magnetite (Fe,O,) particles with monoclonal antibodies directed against a tumor antigen. The preparation maintains both the immunoreactivity of the monoclonal antibody and the full relaxing capability of the magnetite particle. MRI image contrast by spin-echo methods can be easily induced in a concentration range of 1- 10 &of the antibody-coated magnetite particles.

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