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Monoclonal antibodies against LFA-1 or its ligand ICAM-1 accelerate CD2 (T11.1 + T11.2)-mediated T cell proliferation

✍ Scribed by Chantal Cerdan; Carol Lipcey; Marc Lopez; Jacques Nunes; Anne Pierres; Claude Mawas; Daniel Olive


Book ID
113134405
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
684 KB
Volume
123
Category
Article
ISSN
0008-8749

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Proliferative response of resting Tcells generally requires not only cross-linking of theTcell receptor (TcR) but also co-stimulatory signals from accessory molecules. We here have used a "three-cell'' model consisting of: (a) resting human CD4+ T cells as responders; (b) CD3 monoclonal antibody (mA