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Monoclonal anti-idiotypic antibody mimicking a tumor-associated sialogycoprotein antigen induces humoral immune response against human small-cell lung carcinoma

Book ID
121969780
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
146 KB
Volume
6
Category
Article
ISSN
0169-5002

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Monoclonal anti-idiotypic antibody mimic
Monoclonal anti-idiotypic antibody mimicking a tumor-associated sialoglycoprotein antigen induces humoral immune response against human small-cell lung carcinoma
✍ Andreas Barth; Robert Waibel; Rolf A. Stahel πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 French βš– 550 KB

We have previously described the tumor-asrocisited sialoglycoprotein antigen sGP,,,, defined by the murine LAME MAb. The antigen is characterized by strong memlbrane expression in a proportion of small-cell carcinomas of the lung, but little or no expression on normal tissues of epithelial or neural

Tumor-antigen-specific humoral immune re
Tumor-antigen-specific humoral immune response of animals to anti-idiotypic antibodies and comparative serological analysis of patients with small-cell lung carcinoma
✍ Hans-Peter Lehmann; Caroline Zwicky; Robert Waibel; Rolf A. Stahel πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 French βš– 782 KB

## Abstract We have previously developed 3 monoclonal anti‐idiotypic antibodies (Ab2) of LOU rat origin directed against the binding site of the murine monoclonal IgM LAM8, which recognizes the small‐cell lung carcinoma (SCLC)‐associated sialoglycoprotein antigen sGP~90–135~. The aim of this study