Monoclonal and polyclonal antibody responses to the myelin basic protein epitope present in human urine
โ Scribed by John N. Whitaker; Angela McKeehan; Deborah W. Freeman
- Book ID
- 119108812
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 744 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0165-5728
No coin nor oath required. For personal study only.
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Immunochemical analysis of polyclonal antisera from Lewis rats immunized with peptide analogs and subpeptides of residues 72-84 of guinea pig myelin basic protein (MBP) indicated that there were four main epitopic specificities involved: one represented by residues 76-80, one by residues 72-74, one
Studies from our laboratory have shown that region 69-84 (synthetic peptide S49S) of myelin basic protein (MBP) defines an encephalitogenic sequence for experimental allergic encephalomyelitis (EAE) in Lewis rats. The most potent EAE inducers are the guinea pig MBP (Gp-MBP) and region 69-84, known a