Monocarboxylate transporter (MCT)-1 is up-regulated by PPARα
✍ Scribed by Bettina König; Alexander Koch; Karen Giggel; Batsuch Dordschbal; Klaus Eder; Gabriele I. Stangl
- Book ID
- 116271958
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 541 KB
- Volume
- 1780
- Category
- Article
- ISSN
- 0304-4165
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## Abstract Butyrate, a short chain fatty acid (SCFA) produced by bacterial fermentation of undigested carbohydrates in the colon, constitutes the major fuel for colonocytes. We have earlier shown the role of apically localized monocarboxylate transporter isoform 1 (MCT1) in transport of butyrate i
## Abstract Monocarboxylate transporter (MCT)‐1 mediates the transport of ketone bodies and other monocarboxylic acids across the plasma membrane. MCT1 is up‐regulated by peroxisome proliferator‐activated receptor (PPAR)‐α, a transcription factor that mediates the adaptive response to fasting by up