Monoanionic N,N,O-Scorpionate Ligands and their Iron(II) and Zinc(II) Complexes: Models for Mononuclear Active Sites of Non-Heme Iron Oxidases and Zinc Enzymes
✍ Scribed by Alexander Beck; Bernhard Weibert; Nicolai Burzlaff
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 333 KB
- Volume
- 2001
- Category
- Article
- ISSN
- 1434-1948
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✦ Synopsis
The chemical behavior of two bis(3,5-dialkylpyrazol-1-yl)acetic acids and their coordination properties towards ZnCl 2 and FeCl 2 was studied. Reaction of bis(3,5-dimethylpyrazol-1-yl)acetic acid (bdmpza) (1) with ZnCl 2 and FeCl 2 gave the 2:1 complexes [(bdmpza) 2 Zn] (4) and [(bdmpza) 2 Fe] (5). Crystal structures of both complexes were obtained. In contrast, the sterically more hindered ligand bis(3,5-di-tert-butylpyrazol-1-yl)acetic acid (bdtbpza) (3) coordinates only once to zinc(II) resulting in the complex [(bdtbpza)ZnCl] ( ). This provides a structural model complex for the active sites of zinc enzymes such as thermolysin or carboxypeptidase.