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Monoamine re-uptake inhibiting 1-[2-[(phenoxyphenyl)methoxy]ethyl]- piperazines as potential antidepressants

✍ Scribed by J. Wieringa; A. van den Meerendonk; J. Steenvoorden; G. Heeres; F. van Bakel; T. Roeters; R. van der Hulst; A. Den Blanken; D. Leysen; R. Plate; Th. de Boer; H. Rijk

Book ID: 104589497
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 784 KB
Volume: 112
Category: Article
ISSN: 0165-0513
DOI: 10.1002/recl.19931120212

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✦ Synopsis

Abstract

A series of 1‐[2‐[(2‐phenoxyphenyl)methoxy]ethyl]‐4‐(3‐phenylpropyl)piperazines 17–50 (Figure 1) were prepared and tested as inhibitors of biogenic amine re‐uptake. In our search for antidepressants, the relationship between their in vitro and in vivo activity as dopamine‐reuptake inhibitors is described quantitatively by using Retention Index values determined by reversed‐phase liquid chromatography.

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