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Monoamine Oxidase Inhibitors. The Synthesis and Evaluation of a Series of Substituted Alkylhydrazines

โœ Scribed by Drain, D. J.; Howes, J. G. B.; Lazare, R.; Salaman, Ann M.; Shadbolt, R.; Williams, H. W. R.


Book ID
121308352
Publisher
American Chemical Society
Year
1963
Tongue
English
Weight
892 KB
Volume
6
Category
Article
ISSN
0022-2623

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Inhibitors of monoamine oxidase III: 9-s
โœ Beng T. Ho; William M. McIsaac; L. Wayne Tansey; K. E. Walker ๐Ÿ“‚ Article ๐Ÿ“… 1969 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 337 KB

A series of 9-alkyl aromatic 8-carbolines was synthesized and evaluated as inhibitors of mitrochondrial monoamine oxidase. The possible existence of a hydrophobic or hydrophilic region on the enzyme was explored. Substitution of an electron-withdrawing group such as acetyl on N-9 position reduced t