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Monoamine Oxidase Inhibitors and Procedures for their Evaluation In Vivo and In Vitro

✍ Scribed by Ozaki, Masayori; Weissbach, Herbert; Ozaki, Atsuko; Witkop, Bernhard; Udenfriend, Sidney

Book ID: 126288684
Publisher: American Chemical Society
Year: 1960
Tongue: English
Weight: 766 KB
Volume: 2
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm50013a001

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Monoamine oxidase A (MAO-A) inhibition was investigated both in vitro and in vivo in rat brains by using the radioligand, 18 F-fluoroclorgyline (N-[3-(2Ј,4Јdichlorophenoxy)-2-18 F-fluoropropyl]-N-methylpropargylamine). In vitro binding affinities of six compounds, clorgyline, Ro 41-1049, deprenyl, f