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Monoamine oxidase and α-synuclein as targets in Parkinson’s disease therapy

✍ Scribed by Follmer, Cristian


Book ID
121852498
Publisher
Expert Reviews
Year
2014
Tongue
English
Weight
885 KB
Volume
14
Category
Article
ISSN
1473-7175

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A rationale for monoamine oxidase inhibi
✍ Prof. C. W. Olanow 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 719 KB

Neurons in the substantia nigra may be vulnerable to oxidant stress because (a) the metabolism of dopamine generates peroxides. which, in the presence of iron. can lead to the formation of the highly reactive hydroxyl free radical; and (b) neuromelanin within nigral neurons can bind metals such as i