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Mono(2-ethylhexyl)phthalate exhibits genotoxic effects in human lymphocytes and mucosal cells of the upper aerodigestive tract in the comet assay

✍ Scribed by Norbert H Kleinsasser; Ulrich A Harréus; Ernst R Kastenbauer; Barbara C Wallner; Andrea W Sassen; Rainer Staudenmaier; Albert W Rettenmeier

Book ID: 119377787
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 79 KB
Volume: 148
Category: Article
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2003.12.013

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In previous studies, N-(N'-acetyl-L-propyl)-N-nitrosoglycine (APNG) has been shown to be a potent mutagen in a variety of genotoxicity assays and a carcinogen in a limited cancer study. APNG decomposes to a carboxymethyldiazonium ion, which can also be generated from potassium diazoacetate (KDA). KD