Mono-, Di-, or Triazidated Cyclodextrin-Based Polyrotaxanes for Facile and Efficient Functionalization via Click Chemistry
✍ Scribed by Hoon Hyun; Nobuhiko Yui
- Book ID
- 102496725
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 351 KB
- Volume
- 32
- Category
- Article
- ISSN
- 1022-1336
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✦ Synopsis
Abstract
As a feasible way for controlling the density of ligands in polyrotaxanes, azidated polyrotaxanes comprising PEG (MW = 3 000 and 20 000 g · mol^−1^) and mono‐, di‐, or triazidated α‐cyclodextrins are prepared in a water/DMSO solution in a one‐pot synthesis. The azidated polyrotaxanes are then allowed to conjugate with propargyl‐modified mannose as a ligand via click chemistry. As proven by FTIR spectroscopy and ^1^H NMR‐spectroscopy, mannose molecules are efficiently introduced into all of the azide moieties of the polyrotaxanes. The results verify the achievement of ligand‐density‐controlled polyrotaxanes. The functionalized polyrotaxanes can be utilized for a variety of biological applications. magnified image