Monitoring γ-hydroxybutyric acid levels in succinate-semialdehyde dehydrogenase deficiency

Monitoring of 4-hydroxybutyric acid leve

Monitoring of 4-hydroxybutyric acid levels in body fluids during vigabatrin treatment in succinic semialdehyde dehydrogenase deficiency

✍ Katrin Ergezinger; Reinhard Jeschke; Georg Frauendienst-Egger; Herbert Korall; K 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 98 KB

## Abstract We report the successful treatment using low‐dose vigabatrin (21.5–34mg/kg/day) of a 10‐year‐old girl with succinic semialdehyde dehydrogenase (SSADH) deficiency We verified that 4‐hydroxybutyric acid (GHB) concentrations in serum, cerebrospinal fluid, and urine continuously decreased i