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Monitoring the efficiency of iron chelation therapy: the potential of nontransferrin-bound iron

✍ Scribed by R.C. Hider; A.M.N. Silva; M. Podinovskaia; Yongmin Ma


Book ID
110108392
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
216 KB
Volume
1202
Category
Article
ISSN
0890-6564

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The effect of metabolic inhibitors on nontransferrin bound iron transport by K562 cells was investigated. Incubation with 1 microM rotenone, 10 microM antimycin, or 0.5 mM 2,4-dinitrophenol effectively reduced ATP levels by approximately 50%. Both the rate and extent of Fe+3 uptake were impaired in