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Monitoring tablet dissolution with a sodium ion-selective glass electrode

✍ Scribed by William D. Mason; Thomas E. Needham; James C. Price

Publisher: John Wiley and Sons
Year: 1971
Tongue: English
Weight: 238 KB
Volume: 60
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600601146

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✦ Synopsis

The usefulness of the sodium ion-selective electrode (SIE) in measuring the disintegration and dissolution of tablets containing sodium salicylate was evaluated. This potentiometric measurement of sodium appearance in solution was found to agree with spectrophotometric assays forsalicylate and sodium insolution. The SIE employed in this manner provides an accurate, inexpensive, and readily automated methodology for following tablet disintegration and dissolution. Keyphrases 0 Sodium ion-selective glass electrode-monitoring tablet dissolution IJ Dissolution, monitoring tablets-use of sodium ion-selective electrode IJ Potentiometric measurement of sodium-monitoring tablet dissolution a Harvard model 1201. 7 Perkin-Elmer 290 B. 8 Beckman DU.

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