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Monitoring solution-phase combinatorial library synthesis by capillary electrophoresis

✍ Scribed by Hans J. Gaus; Pei-Pei Kung; Doug Brooks; P. Dan Cook; Lendell L. Cummins

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 165 KB
Volume: 61
Category: Article
ISSN: 0006-3592
DOI: 10.1002/(sici)1097-0290(1998)61:3<169::aid-cc4>3.0.co;2-6

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✦ Synopsis

Capillary electrophoresis has been applied to monitor model reactions in solution-phase combinatorial chemistry. In particular, the simultaneous alkylation reactions of secondary amines with a series of benzyl halides has been investigated. Reactant and product concentrations were monitored using capillary electrophoresis in a nonaqueous buffer system. The simplified sample preparation was a key feature making this an attractive method of analysis. The results demonstrate that capillary electrophoresis is a useful tool for monitoring reactions to determine initial rates, rate constants, and extinction correlation coefficients for quantitative analysis in combinatorial chemistry, and is a broadly applicable technique for the analysis of a variety of organic and bioorganic transformations.

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