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Monitoring of Process Streams in the Large-scale Production and Purification of Plasmid DNA for Gene Therapy Applications

✍ Scribed by G. N. M. FERREIRA; J. M. S. CABRAL; D. M. F. PRAZERES

Book ID
118111313
Publisher
Pharmaceutical Press
Year
1999
Tongue
English
Weight
64 KB
Volume
5
Category
Article
ISSN
2042-7158

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## Abstract We set out to investigate if __E. coli__ genotype plays a significant role in host strain selection for optimal processing of plasmid DNA based on both quality and quantity of supercoiling. Firstly 17 __E. coli__ commercial and non‐commercial strains were selected and their available ge